CASE REPORT

Paraneoplastic hyperthyroidism secondary to metastatic choriocarcinoma. Clinical Case Report.

Mendoza M Pedro, Plateado Salazar Erick O, Paul Espinosa Carla J

Department of Endocrinology, La Raza National Medical Center, Mexican Institute of Social Security IMSS, Mexico City

Corresponding Author: Mendoza M Pedro. Department of Endocrinology, La Raza National Medical Center, Mexican Institute of Social Security IMSS, Mexico City, Mexico. E-mail: [email protected] 

Received: June 05, 2023                                                           Published: June 17, 2023

Citation: Mendoza M. Paraneoplastic hyperthyroidism secondary to metastatic choriocarcinoma. Clinical Case Report. Int J Complement Intern Med. 2023;5(1):175–180. DOI: 10. 58349/IJCIM. 1. 5. 2023. 00127

Copyright: ©2023 Pedro. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and build upon your work non-commercially.

Abstract 

Rarely, thyrotoxicosis may arise as a paraneoplastic syndrome, as in the case of choriocarcinoma. Similarities in biological structures between serum human chorionic gonadotropin (HCG) and thyroid stimulating hormone (TSH) allow HCG to exert its effects on the TSH receptor on thyroid membranes. Thyrotoxicosis was presented in a 25-year-old female patient who previously presented deterioration of alertness, intracranial hypertension, with subsequent finding of multiple metastatic lesions, with concentrations of human chorionic gonadotropin up to 500,000 mIU/mL. With adequate evolution after initiation of antithyroid and chemotherapy. 

Objective To report a case of rare pathology and review the literature to know the right approach to a case of paraneoplastic hyperthyroidism. 

Keywords: Hyperthyroidism, Choriocarcinoma, Metastasis

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