EDITORIAL

Effects of Glycemic Index on Neuroplasticity, Systemic Inflammation and Epigenetic Longevity in Man and Animals

Orien L Tulp.1,2 

• .1Professor of Medicine and Graduate Studies, University of Science Art and Technology, Montserrat, British West Indies 
• .2Professor, East-West College of Natural Medicine, Sarasota, FL USA
•  
• Corresponding Author: Orien L Tulp, PhD, MD, FACN, CNS, Professor of Medicine and Graduate Studies, University of Science Art and Technology, Montserrat, British West Indies, and Professor, East-West College of Natural Medicine, Sarasota, FL USA. E-mail: [email protected]/[email protected]
•  

Received: May 13, 2025                                                Published: June 10, 2025

Citation: Tulp OL. Effects of glycemic index on neuroplasticity, systemic inflammation and epigenetic longevity in man and animals. Int J Complement Intern Med. 2025;6(3):293–299. DOI: 10. 58349/IJCIM. 3. 6. 2024. 00149

Copyright: ©2025 Tulp OL. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and build upon your work non-commercially.

Abstract 

The pathophysiologic sequelae of systemic inflammation is a common observation in obesity and T2DM and contributes to the stigmata of the comorbidities linked to the disorder. Multiple factors contribute to the systemic inflammation, including elements of lifestyle, dietary macronutrient, micronutrient, and caloric intake, genetic predisposition, and the magnitude of the excess body fat accretion. The interaction between epigenetic metabolic factors and the above contributors remains unclear but include the quantity, type and glycemic index of the carbohydrates consumed. Carbohydrates with a high glycemic index contribute to greater excursions in glycemic and insulinogenic parameters, increase the generation of reactive oxygen species (ROS) and contribute to neuronal dysregulation and epigenetic senescence in man and animals. 

Keywords: epigenetics, nutrition, carbohydrates, obesity, diabetes, neuroinflammation, neuroapoptosis, senescence, T2DM, Obesity, Nutrition, therapeutics, aging, epigenetics, lifestyle, epidemiology, metabolism, Glycated hemoglobin, wound healing

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